Transcriptional recording sentinel cells as living diagnostics of the human gastrointestinal tract
Dr. Jakob Zimmermann, Gastroenterology and Mucosal Immunology Research Group, Department for Biomedical Research, University of Bern. For more information, please visit the website.
Crohn’s disease is an inflammatory disorder that may affect any segment of the intestinal tract. Diagnosis and treatment could be improved through biomarkers from affected areas but these are poorly accessible. As intestinal bacteria react quickly to environmental changes, they may be used as sentinels reporting on the intestinal milieu. For this, specialized sentinel bacteria have been engineered that report on changes in the gut environment. In this pilot project, we aim to lay the foundation for using sentinel bacteria as a novel precision medicine approach in Crohn’s disease diagnosis.