Bern Center for Precision Medicine (BCPM)

Projects: 1st round

The goal of this 1st round call was to support innovative translational research projects that address key challenge areas in Precision Medicine, with a special focus on the usage of Next Generation Sequencing (NGS). The following seven projects were selected: 

Topic: Hepatology

Predictive factors of cirrhosis regression in patients with advanced chronic liver disease

Annalisa Berzigotti

Topic: Oncology

Preclinical development of an adoptive T cell therapy strategy to treat patients with non-small cell lung cancer

Sean Hall

Topic: Oncology

NMIBC a personalized approach: defining the genomic landscape and response to therapy

Marianna Kruithof-de Julio

Topic: Gastroenterology

A pilot project to define microbiota bottlenecks using the trajectory of subspecies clade allele frequencies through high-definition personalized analysis in individual Crohn’s disease patients and controls

Andrew J. Macpherson

Topic: Gynecology and Obstetrics

Whole genome sequencing and single cell transcriptome analysis of progestin resistance in endometriosis

Konstantinos Nirgianakis

Topic: Oncology

Targeting the niche of drug-tolerant tumor-repopulating cells to eradicate residual disease in breast cancer

Sven Rottenberg

Topic: Dermatology

DisSECt Disease modelling in Skin Explant Cultures

Christoph Schlapbach