The SOCIBP SPHN/PHRT project consists of two parts: The driver SPHN project will create a breakthrough genomics platform to manage and share data across Switzerland to help our clinicians and scientists untangle the complexity of cancer therapy resistance. The PHRT project will put the SPHN driver project into practice by asking how we can best determine the right patients for cancer immunology therapy for solid tumors. This synergy and real-world testing should provide both important new tools for the Swiss and International research community as well as providing insight into the mechanism of resistance for immuno-oncology.